Quantitative determination of Drugs & Pharmaceuticals using p- Chloranilic acid as Reagent
نویسنده
چکیده
Nine drugs viz., Famotidine, Ketorolac tromethamine, Dextromethorphan, Quetiapine, Salmeterol, Sumatriptan, Tamoxifen, Torsemide and Pantoprazole turned the pale yellow colour of reagent viz., p-chloranilic acid, in CH3CN, to purple and exhibited a band at 520nm due to anion of the reagent whose intensity increased with increase in the concentration of the drugs and formed a basis for quantitative determination of the drugs. The composition of each complex is found to be 1:1 and stability of the order of 10. The effect of the concentration reagent, polarity of solvent, interference of excipients have been studied and optimized. The methods have been validated in terms of IVH guidelines and applied to the quantification of pharmaceuticals. The variations of slopes of calibration plots and stability constants are discussed in terms of structures of the drugs.
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